All steroid drugs have a negative effect on the functioning of such an organ as the human liver. The type and type of anabolic drug (pills, injections, chemical formula, etc.), its quantity and duration of the course of administration are taken into account. The first signal that the liver is experiencing toxic effects and overload is the release of specific hepatic chemicals into the blood (AST (GOT), ALT (GPT), etc.). These substances report on the physical state of the liver and the metabolic processes occurring in it during thorough medical examinations. Normally, these indicators do not exceed the value of 37 U / l. In the blood of athletes who use anabolic steroids, these substances are two, even three times more than normal. It is generally accepted that after the end of taking steroid drugs, the liver stops synthesizing these substances and their amount in the blood returns to normal. Let me tell you not always. Sometimes the level of indicators of liver toxicity remains high for many months after the end of steroid use. And even after the level of indicators is normal, it is not known whether damaged liver cells are restored.
Breakdown and elimination from the body of oral drugs is much slower and more difficult than injectables. During the processing of tablet preparations, the liver experiences significant tissue damage. Degeneration of the liver tissue occurs, liver cells are reborn into fatty sinewy clots, cavities filled with blood are formed. This phenomenon in medical practice has received the name “peliosis hepatitis”. With a sufficiently long intake of tablet preparations in large doses, this disease is not uncommon. The ability of hepatic phospholipids to cleanse the body of additional toxins that enter the bloodstream along with food, water, drugs and alcohol is greatly reduced.

Injectable steroids do not pose as much harm to the liver as oral tablet preparations. True, if you make an injection with a non-sterile syringe or dirty hands, microbes and viruses can penetrate the skin directly into the blood. Viral hepatitis B and C, AIDS, many sexually transmitted diseases are also transmitted through the blood. Together, oral and injectable steroids cause nodular formations in the liver tissues, which in the future can degenerate into benign and malignant tumors and neoplasms. Under the influence of the aromatase enzyme, exogenous testosterone is converted into the female hormones estradiol 17 and estrogen. It is the liver that breaks down these substances and deactivates the chemical action of these hormones. If at such moments you take toxic drugs, alcohol, etc., then the liver does not have time to process female sex hormones, and they activate processes such as female-type obesity and gynecomastia.

Studies show that anabolic drugs have a toxic effect not only on the liver, but also on the kidneys. When conducting a comprehensive blood test in athletes using anabolic steroids, the chemical composition of the blood was violated, which our kidneys are responsible for. These are indicators of creatinine (Creatinine B), urea (Urea B), and glomerular fluid filtration rate (eGFR). Normally, these values ​​are not higher than 1.17 for creatinine, 43 for urea, and the filtration rate should not be less than 60 at a rate of 1.73 ml/min. High levels of creatinine indicate overload and heavy training, urea indicates dehydration, and a low filtration rate indicates the initial stage of kidney failure. It is necessary to carefully monitor these indicators, since a constant overload in the work of the kidneys beyond the physiological norm will lead to kidney failure and failure in functionality. A drug such as Parabolan causes a violation of the blood purification processes taking place in the renal lobes. Blood is found in the urine, inflammation of the kidneys (nephritis) is diagnosed. With prolonged use of anabolic steroids, the amount of chemicals excreted in the urine drops, which can cause stone formation and kidney failure, especially in those athletes who have had kidney disease and chronic inflammation.